“In analogy to the current situation in Cosmology, glycans can be considered as the ‘dark matter of the biological universe: a major and critical component that has yet to be fully incorporated into the ‘standard model’ of biology.”Ajit Varki and Stuart Kornfeld, Essentials of Glycobiology, 3rd Edition, 2017.
Welcome to Glyco@Oz
the network connecting Australian glycoscientists
We are the network that connects and informs Australian glycoscientists across institutions, career levels and interest areas.
Do you speak glyco? Your cells do.
Every living cell on this planet is covered by a glycocalyx, which is a dense layer formed by glycoproteins, glycolipids, proteoglycans and polysaccharides. Cell surface, extracellular matrix and also body fluid proteins are extensively modified with specific sugar moieties, so called glycans. These glycans, in conjunction with their respective proteins, form the basis for a universal language (glycome) used between cells that is also abused by pathogens and cancer cells. It is well established that even small changes in the cellular glycosylation can severely affect the function and behaviour of cells. Studies addressing global changes in glycosylation (glycomics) have clearly shown disease-associated alterations of the glycome, but the impact of such changes on the function of individual glycoproteins can just be studied individually for each protein and protein-ligand complex (glycoproteomics).
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